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Notify sufferers that: Tramadol Hydrochloride Prolonged-Launch is for oral use only and may be swallowed whole. The capsule shouldn't be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Extended-Release may perhaps lead to seizures and/or serotonin syndrome with concomitant utilization of serotonergic brokers (such as SRIs, NRIs, and